• Mesenchymal Stem Cell/Red Blood Cell-Inspired Nanoparticle Therapy in Mice with Carbon Tetrachloride-Induced Acute Liver Failure. Liang H, Huang K, Su T, Li Z, Hu S, Dinh PU, Wrona EA, Shao C, Qiao L, Vandergriff AC, Hensley MT, Cores J, Allen T, Zhang H, Zeng Q, Xing J, Freytes DO, Shen D, Yu Z, Cheng K. ACS Nano. 2018 Jun 26. doi: 10.1021/acsnano.8b00553. [Epub ahead of print]

  • Hu S, Ogle B, Cheng K. Body Builder: from Synthetic Cells to Engineered Tissue, Current Opinion in Cell Biology 5: 37-42, 2018.
  • Fagg WS, Liu N, Yang MJ, Cheng K, Chung E, Kim JS, Wu G, Fair J. Magnetic Targeting of Stem Cell Derivatives Enhances Hepatic Engraftment into Structurally Normal Liver. Cell Transplant. 2017:1868-1877. doi: 10.1177/0963689717737320.
  • Vandergriff A, Huang K, Shen D, Hensley MT, Qian L, Caranasos TG, Cheng K. Targeting regenerative exosomes to myocardial infarction using cardiac homing peptide. Theranostics. 2018; 8(7):1869-1878 (Cover Image)
  • Tang J, Su T, Huang K, Dinh PU, Wang Z, Vandergriff AC, Hensley MT, Cores J, Allen T, Li TS, Sproul E, Mihalko E, Lobo LJ, Ruterbories L, Lynch A, Brown AC, Caranasos TG, Shen D, Stouffer GA, Gu Z, Zhang J, Cheng K. Targeted repair of heart injury by stem cells fused with platelet nanovesicles. Nature Biomedical Engineering. 2, 17–26 (2018)

Junnan Tang, Jhon Cores, Ke Huang, Xiaolin Cui, Luo Lan, Jinying Zhang, Taosheng Li, Li Qian, Ke Cheng. Concise Review: Is Cardiac Cell Therapy Dead? Embarrassing trial outcomes and new directions for the future. Stem Cells Translational Medicine. 7:354-359, 2018



Tang J, Cui X, Caranasos TC, Hensley MT, Vandergriff AC, Hartanto Y, Shen D, Zhang H, Zhang J, Cheng K. Heart repair using nanogel encapsulated cardiac stem cells in mice with myocardial infarction. ACS Nano. Accepted 2017.

Cores J, Hensley MT, Kinlaw K, Rikard SM, Dinh PU, Paudel D, Tang J, Vandergriff AC, Allen TA, Li Y, Liu J, Niu B, Chi Y, Caranasos T, Lobo LJ, Cheng K.Safety and Efficacy of Allogeneic Lung Spheroid Cells in a Mismatched Rat Model of Pulmonary Fibrosis. Stem Cells Transl Med. 2017 Aug 7. doi: 10.1002/sctm.16-0374. [Epub ahead of print]

Dinh PC, Cores J, Hensley MT, Vandergriff AC, Tang J, Allen TA, Caranasos TG, Adler KB, Lobo LJ, Cheng K.Derivation of therapeutic lung spheroid cells from minimally invasive transbronchial pulmonary biopsies. Respir Res. 2017 Jun 30;18(1):132. doi: 10.1186/s12931-017-0611-0.

Lan L, Tang J, Nishi K, Yan C, Dinh PU, Cores J, Kudo T, Zhang J, Li T, and Cheng K. Fabrication of Synthetic Mesenchymal Stem Cells for the Treatment of Acute Myocardial Infarction in Mice.  Circulation Research. 2017Mar 15. pii: CIRCRESAHA.116.310374. doi: 10.1161/CIRCRESAHA.116.310374

Tang J, Shen D, Caranasos TG, Wang Z, Allen TA, Vandergriff A, Hensley MT, Dinh PU, Cores J, Li TS, ZhangJ, Kan Q, and Cheng K. Therapeutic microparticles functionalized with biomimetic cardiac stem cell membranes and secretome. Nature Communications. 2017 Jan 3;8:13724. doi: 10.1038/ncomms13724

Tang J, Vandergriff A, Wang Z, Hensley M, Cores J, Allen T, Dinh PU, Zheng J, Caranasos T, Cheng K. A Regenerative Cardiac Patch Formed by Spray Painting of Biomaterials onto the Heart. Tissue Engineering 2017 Jan 9. doi: 10.1089/ten.TEC.2016.0492    

MT Hensley, Tang J, Woodruff K, Defrancesco T, Tou S, Williams CM, Breen M, Meurs K, Keene B, Cheng K. Intracoronary allogeneic cardiosphere-derived stem cells are safe for use in dogs with dilated cardiomyopathy. J Cell Mol Medicine 2017 Mar 15. doi: 10.1111/jcmm.13077

Wang Z, Dong N, Wu Q, Cheng K. Transplantation of human villous trophoblasts preserves cardiac function in mice with acute myocardial infarction. J Cell Mol Med. Accepted February 2017.


Allen TA, Gracieux D, Talib M, Tokarz DA, Hensley MT, Cores J, Vandergriff A, Tang J, de Andrade JB, Dinh PU, Yoder JA, Cheng K. “Angiopellosis as an Alternative Mechanism of Cell Extravasation.” Stem Cells. 2016 Jun 28.

Shen D, Tang J, Hensley MT, Li T, Caranasos TG, Zhang T, Zhang J, Cheng K. “Effects of Matrix Metalloproteinases on the Performance of Platelet Fibrin Gel Spiked With Cardiac Stem Cells in Heart Repair.” Stem Cells Translational Medicine. 2016 Apr 25.


Andrade JN, Tang J, Hensley MT, Vandergriff A, Cores J, Henry E, Allen TA, Caranasos TG, Wang Z, Zhang T, Zhang J, Cheng K. “Rapid and Efficient Production of Coronary Artery Ligation and Myocardial Infarction in Mice Using Surgical Clips.” PLoS One. 2015 Nov 24; 10(11):e0143221.

Vandergriff A, de Andrade JB, Tang J, Hensley MT, and Cheng K. “Intravenous administration of cardiac progenitor cell-derived exosomes mediates heart regeneration after doxorubicin-induced dilated cardiomyopathy.” Stem Cell International. 2015. Epub 2015 August 17.

Tang J, Shen D, Zhang J, Ligler FS, Cheng K. “Bispecific antibodies, nanoparticles and cells: bringing the right cells to get the job done.” Expert Opinion on Biological Therapies. 2015;15(9):1251-5

Cores J, Caranasos TG, Cheng K. “Magnetically Targeted Stem Cell Delivery for Regenerative Medicine.” Journal of Functional Biomaterials. 2015 June 6.

Henry E, Cores J, Hensley MT, Anthony S, Vandergriff A, de Andrade JBM, Allen T, Caranasos TG, Lobo LJ, Cheng K. “Adult Lung Spheroid Cells Contain Progenitor Cells and Mediate Regeneration in Rodents with Bleomycin-Induced Pulmonary Fibrosis.” Stem Cells Translational Medicine. 2015.

Vandergriff A, Hensley TM, Cheng K. “Cryopreservation of Cardiomyocytes.” Methods in Molecular Biology. 1299:153-60. 2015.

Hensley MT, de Andrade J, Meurs K, Keene B, Tang J, Piedrahita J, Caranasos TG, Li TS, Cheng K. “Regenerative potential of canine cardiac stem cells.” Journal of Cellular and Molecular Medicine. 19(8):1805-13. 2015.

Vandergriff A, Hensley MT, Cheng K. “Cryoperservation of cardiomyocytes for cell-based assay.” Journal of Visual Experiments. 2015.

Kanazawa H, Tseliou E, Malliaras K, Yee K, Dawkins JF, De Couto G, Smith RR, Kreke M, Seinfeld J, Middleto RC, Cheng K, Luthringer D, Valle I, Chowdhury S, Fukuda K, Makkar RR, Marbán L . “Cellular post-conditioning: allogeneic cardiosphere-derived cells reduce infarct size and attenuate microvascular obstruction when administered after reperfusion in pigs with acute myocardial infarction.” Circulation Heart Failure. 8(2):322-32. 2015.


Vandergriff A, Hensley TM, Henry ET, Shen D, Anthony S, Zhang J, Cheng K. “Magnetic targeting of cardiosphere-derived stem cells with ferumoxytol nanoparticles for treating rats with myocardial infarction.” Biomaterials. 35:8528-39. 2014.

Cheng K (co-corresponding), Ibrahim A, Hensley MT, Sun B, Liu W, Smith RR, Marbán E. “CD90/Thy-1-negative cardiosphere-derived cells exhibit augmented regenerative potency in humans and mice with myocardial infarction.” Journal of the American Heart Association. 2014. In press.

Cheng K (co-corresponding), Shen D, Hensley TM, Sun D, Malliaras K, De Couto G, Middleton RC, Marbán E . “Magnetic antibody-linked nanomatchmakers for therapeutic cell targeting.” Nature Communications. 5:4880. 2014.

Xie Y, Ibrahim A, Cheng K, Malliaras K, Shen D, Sun B, Cho HC, Marbán E . “Human Cardiosphere-derived Cells Stimulate Cardiomyocyte Proliferation via β1 Integrin Signaling.” Stem Cells. 2014. Epub ahead of print.

Ibrahim A, Cheng K, Marbán E . “Exosomes as critical agents of cardiac regeneration triggered by cell therapy.” Stem Cell Reports. 2:606-19. 2014.

Aminzadeh MA, Tseliou E, Sun B, Cheng K, Malliaras K, Makkar RR, Marbán E . “Therapeutic efficacy of cardiosphere-derived cells in a transgenic mouse model of nonischemic dilated cardiomyopathy.” European Heart Journal. 2014.Epub ahead of print.

Cheng K, Malliaras K, Smith RR, Shen D Sun B, Blusztajn A, Xie Y, Ibrahim A, Aminzadeh MA, Liu W, Li TS, De Robertis MA, Marbán L, Czer LS, Trento A, Marbán E . “Human cardiosphere-derived cells from advanced heart failure patients exhibit augmented functional potency in a mouse model of myocardial infarction.” Journal of the American College of Cardiolology Heart Failure. 2:49-61. 2014.

Malliaras K, Makkar RR, Smith RR, Cheng K, Wu E, Bonow RO, Marbán L, Mendizabal A, Cingolani E, Johnston PV, Gerstenblith G, Schuleri KH, Lardo AC, Marbán E . “Intracoronary cardiosphere-derived cells after myocardial infarction: evidence of therapeutic regeneration in the final 1-year results of the CADUCEUS trial (CArdiosphere-Derived aUtologous stem CElls to reverse ventricUlar dySfunction).” Journal of the American College of Cardiolology. 63:110-22. 2014.


Malliaras K, Zhang Y, Seinfeld J, Galang G, Tseliou E, Cheng K, Sun B, Aminzadeh M, Marbán E . “Cardiomyocyte proliferation and progenitor cell recruitment underlie therapeutic regeneration after myocardial infarction in the adult mouse heart.” EMBO Molecular Medicine. 5:191-209. 2013.

Malliaras K, Smith RR, Kanazawa H, Yee K, Seinfeld J, Tseliou E, Dawkins JF, Kreke M, Cheng K, Luthringer D, Ho CS, Blusztajn A, Valle I, Chowdhury S, Makkar RR, Dharmakumar R, Li D, Marbán L, Marbán E . “Validation of contrast-enhanced MRI to monitor regenerative efficacy after cell therapy in a porcine model of convalescent myocardial infarction.” Circulation. 128:2764-75. 2013.


Makkar RR, Smith RR, Cheng K, Malliaras K, Thomson LE, Berman D, Czer LS, Marbán L, Mendizabal A, Johnston PV, Russell SD, Schuleri KH, Lardo AC, Gerstenblith G, Marbán E . “Intracoronary cardiosphere-derived cells for heart regeneration after myocardial infarction (CADUCEUS): a prospective, randomised phase 1 trial.” Lancet. 379:895-904. 2012.

Cheng K, Blusztajn A, Shen D, Li TS, Sun B, Galang G, Zarembinski TI, Prestwich GD, Marbán E, Smith RR, Marbán L . “Functional performance of human cardiosphere-derived cells delivered in an in situ polymerizable hyaluronan-gelatin hydrogel.” Biomaterials. 33:5317-24. 2012.

Shen D, Cheng K (co-corresponding author), Marbán E . “Dose-dependent functional benefit of human cardiosphere transplantation in mice with acute myocardial infarction.” Journal of Cellular and Molecular Medicine. 16:2112-6. 2012.

Cheng K, Shen D, Xie Y, Cingolani E, Malliaras K, Marbán E . “Mechanism of extravasation of infused regenerative cells from microvessels into tissue parenchyma.” Stem Cells. 30:2835-42. 2012.

Lai Y, Cheng K (co-first author), Kisaalita WS . “Three Dimensional Neuronal Cell Cultures More Accurately Model Voltage Gated Calcium Channel Functionality in Freshly Dissected Nerve Tissue.” Plos One. 7:e45074. 2012.

Cheng K, Malliaras K, Shen D, Smith J, Houde C, Galang G, Sun B, Marbán E . “Intramyocardial injection of platelet gel promotes endogenous repair and augments cardiac function in rats with myocardial infarction.” Journal of the American College Cardiology. 59:245-53. 2012.

Cheng K, Shen D, Smith J, Galang G, Sun B, Zhang J, Marbán E . “Transplantation of platelet gel spiked with cardiosphere-derived cells boosts structural and functional benefits relative to gel transplantation alone in rats with myocardial infarction.” Biomaterials. 33:2872-9. 2012.

Cheng K, Blusztajn A, Shen D, Li TS, Sun B, Galang G, Zarembinski TI, Prestwich GD, Marbán E, Smith RR, Marbán L . “Functional performance of human cardiosphere-derived cells delivered in a Hyaluronan-Gelatin hydrogel.” Biomaterials. 33:5317-24. 2012.

Cheng K, Malliaras K, Li T-S, Sun B, Houde C, Galang G, Matsushita N, Marbán E . “Magnetic enhancement of cell retention, engraftment and functional benefit after intracoronary delivery of cardiac-derived stem cells in a rat model of ischemia/reperfusion.” Cell Transplantation. 21:1121-35. 2012.