Publications

2017

Lan L, Tang J, Nishi K, Yan C, Dinh PU, Cores J, Kudo T, Zhang J, Li T, and Cheng K. Fabrication of Synthetic Mesenchymal Stem Cells for the Treatment of Acute Myocardial Infarction in Mice.  Circulation Research. 2017Mar 15. pii: CIRCRESAHA.116.310374. doi: 10.1161/CIRCRESAHA.116.310374

Tang J, Shen D, Caranasos TG, Wang Z, Allen TA, Vandergriff A, Hensley MT, Dinh PU, Cores J, Li TS, ZhangJ, Kan Q, and Cheng K. Therapeutic microparticles functionalized with biomimetic cardiac stem cell membranes and secretome. Nature Communications. 2017 Jan 3;8:13724. doi: 10.1038/ncomms13724

Tang J, Vandergriff A, Wang Z, Hensley M, Cores J, Allen T, Dinh PU, Zheng J, Caranasos T, Cheng K. A Regenerative Cardiac Patch Formed by Spray Painting of Biomaterials onto the Heart. Tissue Engineering 2017 Jan 9. doi: 10.1089/ten.TEC.2016.0492    

MT Hensley, Tang J, Woodruff K, Defrancesco T, Tou S, Williams CM, Breen M, Meurs K, Keene B, Cheng K. Intracoronary allogeneic cardiosphere-derived stem cells are safe for use in dogs with dilated cardiomyopathy. J Cell Mol Medicine 2017 Mar 15. doi: 10.1111/jcmm.13077

Wang Z, Dong N, Wu Q, Cheng K. Transplantation of human villous trophoblasts preserves cardiac function in mice with acute myocardial infarction. J Cell Mol Med. Accepted February 2017.

2016 

Allen TA, Gracieux D, Talib M, Tokarz DA, Hensley MT, Cores J, Vandergriff A, Tang J, de Andrade JB, Dinh PU, Yoder JA, Cheng K. “Angiopellosis as an Alternative Mechanism of Cell Extravasation.” Stem Cells. 2016 Jun 28.

Shen D, Tang J, Hensley MT, Li T, Caranasos TG, Zhang T, Zhang J, Cheng K. “Effects of Matrix Metalloproteinases on the Performance of Platelet Fibrin Gel Spiked With Cardiac Stem Cells in Heart Repair.” Stem Cells Translational Medicine. 2016 Apr 25.

2015

Andrade JN, Tang J, Hensley MT, Vandergriff A, Cores J, Henry E, Allen TA, Caranasos TG, Wang Z, Zhang T, Zhang J, Cheng K. “Rapid and Efficient Production of Coronary Artery Ligation and Myocardial Infarction in Mice Using Surgical Clips.” PLoS One. 2015 Nov 24; 10(11):e0143221.

Vandergriff A, de Andrade JB, Tang J, Hensley MT, and Cheng K. “Intravenous administration of cardiac progenitor cell-derived exosomes mediates heart regeneration after doxorubicin-induced dilated cardiomyopathy.” Stem Cell International. 2015. Epub 2015 August 17.

Tang J, Shen D, Zhang J, Ligler FS, Cheng K. “Bispecific antibodies, nanoparticles and cells: bringing the right cells to get the job done.” Expert Opinion on Biological Therapies. 2015;15(9):1251-5

Cores J, Caranasos TG, Cheng K. “Magnetically Targeted Stem Cell Delivery for Regenerative Medicine.” Journal of Functional Biomaterials. 2015 June 6.

Henry E, Cores J, Hensley MT, Anthony S, Vandergriff A, de Andrade JBM, Allen T, Caranasos TG, Lobo LJ, Cheng K. “Adult Lung Spheroid Cells Contain Progenitor Cells and Mediate Regeneration in Rodents with Bleomycin-Induced Pulmonary Fibrosis.” Stem Cells Translational Medicine. 2015.

Vandergriff A, Hensley TM, Cheng K. “Cryopreservation of Cardiomyocytes.” Methods in Molecular Biology. 1299:153-60. 2015.

Hensley MT, de Andrade J, Meurs K, Keene B, Tang J, Piedrahita J, Caranasos TG, Li TS, Cheng K. “Regenerative potential of canine cardiac stem cells.” Journal of Cellular and Molecular Medicine. 19(8):1805-13. 2015.

Vandergriff A, Hensley MT, Cheng K. “Cryoperservation of cardiomyocytes for cell-based assay.” Journal of Visual Experiments. 2015.

Kanazawa H, Tseliou E, Malliaras K, Yee K, Dawkins JF, De Couto G, Smith RR, Kreke M, Seinfeld J, Middleto RC, Cheng K, Luthringer D, Valle I, Chowdhury S, Fukuda K, Makkar RR, Marbán L . “Cellular post-conditioning: allogeneic cardiosphere-derived cells reduce infarct size and attenuate microvascular obstruction when administered after reperfusion in pigs with acute myocardial infarction.” Circulation Heart Failure. 8(2):322-32. 2015.

2014

Vandergriff A, Hensley TM, Henry ET, Shen D, Anthony S, Zhang J, Cheng K. “Magnetic targeting of cardiosphere-derived stem cells with ferumoxytol nanoparticles for treating rats with myocardial infarction.” Biomaterials. 35:8528-39. 2014.

Cheng K (co-corresponding), Ibrahim A, Hensley MT, Sun B, Liu W, Smith RR, Marbán E. “CD90/Thy-1-negative cardiosphere-derived cells exhibit augmented regenerative potency in humans and mice with myocardial infarction.” Journal of the American Heart Association. 2014. In press.

Cheng K (co-corresponding), Shen D, Hensley TM, Sun D, Malliaras K, De Couto G, Middleton RC, Marbán E . “Magnetic antibody-linked nanomatchmakers for therapeutic cell targeting.” Nature Communications. 5:4880. 2014.

Xie Y, Ibrahim A, Cheng K, Malliaras K, Shen D, Sun B, Cho HC, Marbán E . “Human Cardiosphere-derived Cells Stimulate Cardiomyocyte Proliferation via β1 Integrin Signaling.” Stem Cells. 2014. Epub ahead of print.

Ibrahim A, Cheng K, Marbán E . “Exosomes as critical agents of cardiac regeneration triggered by cell therapy.” Stem Cell Reports. 2:606-19. 2014.

Aminzadeh MA, Tseliou E, Sun B, Cheng K, Malliaras K, Makkar RR, Marbán E . “Therapeutic efficacy of cardiosphere-derived cells in a transgenic mouse model of nonischemic dilated cardiomyopathy.” European Heart Journal. 2014.Epub ahead of print.

Cheng K, Malliaras K, Smith RR, Shen D Sun B, Blusztajn A, Xie Y, Ibrahim A, Aminzadeh MA, Liu W, Li TS, De Robertis MA, Marbán L, Czer LS, Trento A, Marbán E . “Human cardiosphere-derived cells from advanced heart failure patients exhibit augmented functional potency in a mouse model of myocardial infarction.” Journal of the American College of Cardiolology Heart Failure. 2:49-61. 2014.

Malliaras K, Makkar RR, Smith RR, Cheng K, Wu E, Bonow RO, Marbán L, Mendizabal A, Cingolani E, Johnston PV, Gerstenblith G, Schuleri KH, Lardo AC, Marbán E . “Intracoronary cardiosphere-derived cells after myocardial infarction: evidence of therapeutic regeneration in the final 1-year results of the CADUCEUS trial (CArdiosphere-Derived aUtologous stem CElls to reverse ventricUlar dySfunction).” Journal of the American College of Cardiolology. 63:110-22. 2014.

2013

Malliaras K, Zhang Y, Seinfeld J, Galang G, Tseliou E, Cheng K, Sun B, Aminzadeh M, Marbán E . “Cardiomyocyte proliferation and progenitor cell recruitment underlie therapeutic regeneration after myocardial infarction in the adult mouse heart.” EMBO Molecular Medicine. 5:191-209. 2013.

Malliaras K, Smith RR, Kanazawa H, Yee K, Seinfeld J, Tseliou E, Dawkins JF, Kreke M, Cheng K, Luthringer D, Ho CS, Blusztajn A, Valle I, Chowdhury S, Makkar RR, Dharmakumar R, Li D, Marbán L, Marbán E . “Validation of contrast-enhanced MRI to monitor regenerative efficacy after cell therapy in a porcine model of convalescent myocardial infarction.” Circulation. 128:2764-75. 2013.

2012

Makkar RR, Smith RR, Cheng K, Malliaras K, Thomson LE, Berman D, Czer LS, Marbán L, Mendizabal A, Johnston PV, Russell SD, Schuleri KH, Lardo AC, Gerstenblith G, Marbán E . “Intracoronary cardiosphere-derived cells for heart regeneration after myocardial infarction (CADUCEUS): a prospective, randomised phase 1 trial.” Lancet. 379:895-904. 2012.

Cheng K, Blusztajn A, Shen D, Li TS, Sun B, Galang G, Zarembinski TI, Prestwich GD, Marbán E, Smith RR, Marbán L . “Functional performance of human cardiosphere-derived cells delivered in an in situ polymerizable hyaluronan-gelatin hydrogel.” Biomaterials. 33:5317-24. 2012.

Shen D, Cheng K (co-corresponding author), Marbán E . “Dose-dependent functional benefit of human cardiosphere transplantation in mice with acute myocardial infarction.” Journal of Cellular and Molecular Medicine. 16:2112-6. 2012.

Cheng K, Shen D, Xie Y, Cingolani E, Malliaras K, Marbán E . “Mechanism of extravasation of infused regenerative cells from microvessels into tissue parenchyma.” Stem Cells. 30:2835-42. 2012.

Lai Y, Cheng K (co-first author), Kisaalita WS . “Three Dimensional Neuronal Cell Cultures More Accurately Model Voltage Gated Calcium Channel Functionality in Freshly Dissected Nerve Tissue.” Plos One. 7:e45074. 2012.

Cheng K, Malliaras K, Shen D, Smith J, Houde C, Galang G, Sun B, Marbán E . “Intramyocardial injection of platelet gel promotes endogenous repair and augments cardiac function in rats with myocardial infarction.” Journal of the American College Cardiology. 59:245-53. 2012.

Cheng K, Shen D, Smith J, Galang G, Sun B, Zhang J, Marbán E . “Transplantation of platelet gel spiked with cardiosphere-derived cells boosts structural and functional benefits relative to gel transplantation alone in rats with myocardial infarction.” Biomaterials. 33:2872-9. 2012.

Cheng K, Blusztajn A, Shen D, Li TS, Sun B, Galang G, Zarembinski TI, Prestwich GD, Marbán E, Smith RR, Marbán L . “Functional performance of human cardiosphere-derived cells delivered in a Hyaluronan-Gelatin hydrogel.” Biomaterials. 33:5317-24. 2012.

Cheng K, Malliaras K, Li T-S, Sun B, Houde C, Galang G, Matsushita N, Marbán E . “Magnetic enhancement of cell retention, engraftment and functional benefit after intracoronary delivery of cardiac-derived stem cells in a rat model of ischemia/reperfusion.” Cell Transplantation. 21:1121-35. 2012.