Journal of Cellular and Molecular Medicine
© Foundation for Cellular and Molecular Medicine/John Wiley & Sons Ltd
All articles accepted from 12 September 2012 are published under the terms of the Creative Commons Attribution License. Articles accepted before this date were published under the agreement as stated in the final article.
Edited By: Stefan N. Constantinescu
Impact Factor: 4.938
ISI Journal Citation Reports © Ranking: 2015: 17/124 (Medicine Research & Experimental); 44/187 (Cell Biology)
Online ISSN: 1582-4934
Spray Painting Biomaterials Onto Heart Surface Promotes Cardiac Repair After Myocardial Infarction
New Rochelle, NY, March 21, 2017—Researchers have demonstrated the effectiveness of a minimally invasive method to form a regenerative cardiac patch that promotes repair of damaged cardiac tissue in a mouse model of a heart attack. Biomaterials sprayed onto the heart formed a platelet fibrin gel, called a cardiac patch, that helps the heart heal without the need for sutures or glue, as described in an article published in Tissue Engineering, Part C, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers. The article is available free on the Tissue Engineering website until April 21, 2017.
Junnan Tang, Adam Vandergriff, and coauthors from University of North Carolina at Chapel Hill and UNC Eshelman School of Pharmacy, North Carolina State University and NC State College of Veterinary Medicine (Raleigh), The First Affiliated Hospital of Zhengzhou University (China), and Soochow University (Suzhou, China) report on the materials used to form the platelet fibrin gel and the delivery method they used.
In the article entitled “A Regenerative Cardiac Patch Formed by Spray Painting of Biomaterials Onto the Heart,” the researchers showed that the sprayed-on materials were non-toxic to the heart muscle, would adhere to the heart and degrade over time, and could release a variety of growth factors to promote cardiac repair.
“The spray painting method, as described in this manuscript, is an excellent example of how tissue engineering has evolved since the 1990s,” says Methods Co-Editor-in-Chief John A. Jansen, DDS, PhD, Professor and Head, Department of Biomaterials, Radboud University Medical Center, The Netherlands. “The described delivery method is easy to apply in clinics and shows significant potential for patient treatment.”
Research reported in this publication was supported by the National Institutes of Health under Award Number HL123920. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
Congrats to Lan and Junnan. A good collaboration with Professor Tao-sheng Li at Nagasaki University.
Junnan’s synthetic cell-mimicking microparticles paper has been published in Nature Communications.
Junnan’s biomaterials spray paper has been accepted by Tissue Engineering.
Taylor’s dog stem cell paper has been approved for publication in Journal of Cellular and Molecular Medicine.
Congratulations to all of you for your great work!!
Dr. Cheng has been selected as one of 22 faculty to be named an University Faculty Scholar in recognition for his research. Full article is found here.
Tyler Allen was selected as a finalist for the American Society for Cell Biology’s Kaluza Prizes supported by Beckman Coulter. He won for discovering a novel mechanism that non-leukocytic cells employ to transmigrate from blood vessels to surrounding tissue when injected intravenously.
Li is a cardiologist from Hebei, China. She will be focusing on cardiac regeneration.
Tyler’s work on Angiopellosis was published in Stem Cells
Nice Job Adam!